Open Access online publishing journal from Africa

ISSN; 2411-1376 

An African Official Scientific journal

​​Original Research Paper 1

Synthesis, Evaluation and Molecular docking studies of some Novel Pyrazolo [3,4-d] pyrimidine derivatives Associated with 7-Methoxy Quinoline
            J. C. Dharshan, K. A. Vishnumurthy*, Y. D. Bodke, N. D.Jayanna, R. Mohammed Shafeeulla

 Abstract:
Pyrazolo[3,4- d]pyrimidine derivatives were synthesized from 4-hydrazino-7-methoxy quinoline(2)with ethoxymethylenecyanoacetate afforded ethyl 5-amino-1-(7-methoxyquinolin-4-yl)-1H-pyrazole-4-carboxylate(3). The compound (3) washydrolysed to get 5-amino-1-(7-methoxyquinolin-4-yl)-1H-pyrazole-4-carboxylic acid (4) and then reacted with acetic anhydride to afford 1-(7-methoxyquinolin-4-yl)-6-methylpyrazolo[3,4-d][1,3]oxazin-4(1H)-one(5), which was condensed with different aromatic amines to give a series of 5-substituted 1-(7-methoxyquinolin-4-yl)-6-methyl-5-aryl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one(6). The newly synthesized title compounds were characterized and evaluatedfor their antibacterial, antioxidant activity and molecular docking studies.

 
Review Paper 1

Triazole: A Potential Anticancer Agent
             Niranjan Kaushik , Nitin Kumar, Anoop Kumar

Abstract:
Despite a significant work on 1, 2, 4-triazoles, continuous efforts are still being made to identify novel heterocyclic compounds with potent biological activities. Scientists develop a lot of new compounds having 1, 2, 4-triazole nucleus and screened them for their different biological activities such as antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antimalarial, antiulcer, antihistaminic, antiprotozoal, antitubercular, antiviral and anticancer. This review focuses on the various synthetic approaches of triazole derivatives and their anticancer activity. 

 
Review Paper 2

Buccal Drug Delivery System: A Review
           Mishra Amul*, Bharkatiya Meenakshi and Marothia Deepak & Patel harshna

 Abstract:
Bioadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the midst of the surfaces of the biological substrate and the natural or synthetic polymers, which allows the polymer to adhere to the biological surface for an extended period of time. [1-4] Bioadhesive polymeric systems have been used since extent in the development of products for various biomedical applications which include denture adhesives and surgical glue. Considerable attention has been focused in recent years on the delivery of drugs through the oral mucosa which have a high first pass metabolism or degrade in the gastrointestinal tract. Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity. Unlike oral drug delivery, which presents a hostile environment for drugs, especially proteins and polypeptides, due to acid hydrolysis and the hepatic first-pass effect, the mucosal lining of buccal tissues provides a much milder environment for drug absorption. Mucoadhesive controlled-release devices can improve the effectiveness of a drug by maintaining the drug concentration between the effective and toxic levels, inhibiting the dilution of the drug in the body fluids, and allowing targeting and localization of a drug at a specific site. Mucoadhesive characteristics are a factor of both the bioadhesive polymer and the medium in which the polymer will reside. Buccal dosage forms can be of Matrix or Reservoir types. However, this route could become a significant means for the delivery of a range of active agents in the coming years, if the barriers to buccal drug delivery are overcome.

Original Research paper 2

Novel UV and Visible Spectrophotometric methods for the analysis of Empagliflozin a type 2 diabetic drug in bulk and pharmaceutical formulations.
          Jyothirmai N*1, Anil Kumar M2 and Nagaraju B3

 Abstract:
Simple, sensitive and accurate UV and two visible spectrophotometric methods were developed for the analysis of Empagliflozin in pharmaceutical formulations. Method M1 based on the UV absorption of drug in UV region that shows absorption maxima at 247nm. Method M2 and M3 based on the oxidative coupling reaction of drug with 1 10 phenanthroline and Potassium ferricyanide that shows maximum absorbance at 438nm and 782nm for method M2 and M3 respectively. Linearity range was found to be 2-12μg/ml for UV method [M1], 5-30μg/ml for 1 10 phenanthroline method [M2] and 10-60μg/ml for Potassium ferricyanide method [M3]. The methods were validated as per ICH guidelines. The proposed methods have been applied for the estimation of Empagliflozin in tablets. The developed method was simple, accurate, reliable and economical. The proposed method is specific without and interference of excepients and hence can be used for the routine analysis of Empagliflozin in bulk and in pharmaceutical formulation. 

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