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Volume 4 Issue 1

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Open Access online publishing journal from Africa

ISSN; 2411-1376 

An African Official Scientific journal

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Original Research Paper

Title:Skeletal Muscle Relaxant Activity of Aqueous Extract of Carica Papaya Leaves on Wistar Rats

Authors: Aparna S*, Gopala Krishna Ch, Gopi M, Ashok Kumar D, Fathima Sk Sudhakar Babu A M S

Affiliation: Department of Pharmacology, A M Reddy Memorial College of Pharmacy, Petlurivaripalem, Narasaraopet, Guntur [DT], Andhra Pradesh.522601

Article ID:journal de Afrikana, 2015, 2(3); 44-52

Abstract:
Skeletal muscle relaxant activity of the aqueous leaf extract of Carica Papaya was investigated by testing the effects of the extract on wistar rat using rota-rod apparatus model, inclined screen test, climbing test. Experiments were carried out on male rat and the animals were randomly allotted to the different control and test groups. The extracts (aqueous) contain alkaloids, carpine, pseudocarpine, glycosides, saponin, and flavonoids. It was found that aqueous extracts up to a dose of 2000 mg/kg body weight, did not show any toxic manifestations or death. The extract was administered orally at a dose of 200 mg/kg. Diazepam in a dose of 4 mg/kg (s.c.) was used as a standard. Aqueous extract at the dose level of 200 mg/kg body weight showed significant skeletal muscle relaxant activity. On the bases of these results we can conclude that the Carica papaya may be used to develop herbal medicines against the same.

Key Words:  Carica papaya, Muscle relaxant, Rota-rod, Flavonoids, Diazepam

Volume 2 Issue 3