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International Journal of Medical Science and Public Health

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The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre

Abhishek Verma, Somya Sinha, N K Panicker.

Abstract
Background: Hepatic disorders are prevalent in all ages. They are challenging to both pathologist as well as clinician in view of the ill-understood etiopathogenesis. Histological assessment of the liver and thus, liver biopsy is a cornerstone in the evaluation and management of patient with chronic liver disease.

Objective: To study histological spectrum in patient of chronic liver diseases, correlate clinical and biochemical features with morphology on liver biopsy and to evaluate the role of liver biopsy in the diagnosis and management of Chronic Liver Disease.

Materials and Methods: This study is based on liver biopsies obtained from 62 patients with suspicion of Chronic Liver Disease based on clinical features and findings on other investigations. Relevant biochemical and other investigations were done before liver biopsy was resorted to. The size of the intact liver biopsy obtained ranged from 1.5 to 2.5 cms though fragmented biopsy was also obtained in certain cases and was subjected to routine H & E staining and special stains in some cases were performed.

Result: Out of 62 biopsies performed, fatty liver due to Non- alcoholic steatohepatitis (NASH) was seen in 27 % of cases followed by alcoholic cirrhosis in 19 % of cases while least case was found of hepatitis C in only 03 % cases . Males were affected more.

Conclusion: Liver biopsy study is the gold standard for diagnosis of chronic liver diseases.

Key words: Liver biopsy, chronic liver diseases, Clinicopathological correlation


 
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How to Cite this Article
Pubmed Style

Verma A, Sinha S, Panicker NK. The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre. Int J Med Sci Public Health. 2016; 5(12): 2615-2619. doi:10.5455/ijmsph.2016.25072016550


Web Style

Verma A, Sinha S, Panicker NK. The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre. www.scopemed.org/?mno=237243 [Access: January 16, 2017]. doi:10.5455/ijmsph.2016.25072016550


AMA (American Medical Association) Style

Verma A, Sinha S, Panicker NK. The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre. Int J Med Sci Public Health. 2016; 5(12): 2615-2619. doi:10.5455/ijmsph.2016.25072016550


Vancouver/ICMJE Style

Verma A, Sinha S, Panicker NK. The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre. Int J Med Sci Public Health. (2016), [cited January 16, 2017]; 5(12): 2615-2619. doi:10.5455/ijmsph.2016.25072016550


Harvard Style

Verma, A., Sinha, S. & Panicker, N. K. (2016) The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre. Int J Med Sci Public Health, 5 (12), 2615-2619. doi:10.5455/ijmsph.2016.25072016550


Turabian Style

Verma, Abhishek, Somya Sinha, and N K Panicker. 2016. The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre. International Journal of Medical Science and Public Health, 5 (12), 2615-2619. doi:10.5455/ijmsph.2016.25072016550


Chicago Style

Verma, Abhishek, Somya Sinha, and N K Panicker. "The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre." International Journal of Medical Science and Public Health 5 (2016), 2615-2619. doi:10.5455/ijmsph.2016.25072016550


MLA (The Modern Language Association) Style

Verma, Abhishek, Somya Sinha, and N K Panicker. "The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre." International Journal of Medical Science and Public Health 5.12 (2016), 2615-2619. Print. doi:10.5455/ijmsph.2016.25072016550


APA (American Psychological Association) Style

Verma, A., Sinha, S. & Panicker, N. K. (2016) The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy – A study in tertiary health centre. International Journal of Medical Science and Public Health, 5 (12), 2615-2619. doi:10.5455/ijmsph.2016.25072016550



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