| EA MMA | 360 | |
| EA Sports Grand Slam Tennis | 360 | |
| EA Sports MMA | 360 | |
| EA Sports UFC | 360 | |
| Earth Defence Force X | 360 | |
| Earth Defence Force: Insect Armageddon | 360 | |
| Earth Defense Force 4 | 360 | |
| Earth No More | 360 | |
| Earthworm Jim | XLA | |
| Earthworm Jim HD | XLA | |
| Eat Lead: The Return of Matt Hazard | 360 | |
| Edge of Twilight | 360 | |
| Eggo Mania | XBX | |
| Elder Scrolls III: Morrowind | XBX | |
| Elder Scrolls IV: Oblivion | 360 | |
| Elder Scrolls V: Skyrim | 360 | |
| Elveon | 360 | |
| Enchant Arm | 360 | |
| Enchanted Arms | 360 | |
| Enclave | XBX | |
| Enclave 2 | XBX | |
| Enemy Territory: Quake Wars | 360 | |
| England International Football | XBX | |
| Enslaved | 360 | |
| Enter the Matrix | XBX | |
| Epic Mickey 2 | 360 | |
| Eragon | 360 | |
| Eragon | XBX | |
| ESPN Games X Snowboarding 2 | XBX | |
| ESPN International Winter Games | XBX | |
| ESPN International Winter Sports | XBX | |
| ESPN NFL 2K5 | XBX | |
| ESPN NFL Football | XBX | |
| ESPN X Games Skateboarding | XBX | |
| Eternal Sonata | 360 | |
| Every Extend Extra Extreme | XLA | |
| Every Party | 360 | |
| Evil Dead Regeneration | XBX | |
| Evil Dead: A FistFull Of Boomstick | XBX | |
| Evolution Skateboarding | XBX | |
| Extreme Force: Grant City Anti-Crime | XBX |