Whenever the moon is visible at night shoot it with the sniper rifle to make the moon bigger or smaller.

On the second island (Staunton Island), go to the left of the main entrance of the car park that was used in the Kingdom Come mission. Go up the stairway you find up the alleyway with a car and park the car by the wall to the right. The wall is too high to jump on so you will need the car. Jump on the car, then on the wall and you will be on a flat roof. Jump off the wall to the area where you see all the metal fire escape stairways and look around. You will then see a message on one of the walls that reads: “You werent supposed to be able get here you know”.

When not going through a normal mission, get in an Ambulance and press R3.

Save 35 pedestrians and a health refill will appear outside any of your save points.

Save 70 pedestrians and an adrenaline pill will appear outside any of your save points.

Complete the Ambulance level 12 and Infinite Run will be granted.

NOTE:You do not have to save the pedestrians consecutively. You can do it as you go through the game.

While not doing a normal mission, get in a Fire Truck and press R3. There is a Fire Station on each island. Put out 20 fires on each island and a Flame-thrower will always appear at one of your three save points.

NOTE: The fire missions do not have to be done consecutively. Just make sure you have put out 20 fires in each area.

While not doing a normal mission, get into a law enforcement vehicle (Police Car, Enforcer, FBI Car, or Tank) and press R3. In this mode you must chase down criminals and kill them.
Kill 20 criminals on each island and you will be rewarded with a total of 6 Police Bribes at your save point (1 for each set of 10 killed. You must kill criminals on every island to receive all 6 Police Bribes, however. This means killing 20 criminals on each island. Killing two sets of 10 criminals (20 total) in Portland will give you all the Police Bribes (2 total) you can get from that island, and so on.

NOTE: The criminal kills do not have to be done consecutively. Just be sure to kill 20 on each island while in Vigilante mode.

Get a normal car and cruise the streets until you find a hooker drive up next to her (make sure she is standing next to the drivers door) and she will talk to you for a couple of minutes then she will walk around to the other side of the car and get in. Drive to a dark place (an alley, your hideout etc.) and park the car but do not get out. The car will start shaking and your health will go up. Then you have two choices:
1)Stay still and let her get out then beat her up to get your money back, or
2) tap the gas right before she gets out then park the car and watch the car start shaking again which saves time since it costs a dollar a second when she is in the car.

Damaged vehicles can be repaired free at any hideout by parking the vehicle in your garage and get out of the car, leave to let the door close then return and any cars in your garage will be repaired.

The longer you run the longer you can run without taking a break. But if you continue to tap "X" over and over again you can run forever and gain your stamina to the max.

After you pay to repair your car in the Pay 'N Spray, drive back in and you can get a free paint job.

By using the ''Jumping Cars'' trick, you can access other parts of the city you can't in the beginning of the game, from the broken down bridges. Just go to the bridge you want to cross, and use the ''Jumping Cars'' trick when your just about to hit the edge of the bridge. You will then cross the bridge safely (might take a try or two), and be able to try out some new city life!

Just set your console and the game language to English, this allows you to play the game without censorship.
Now you can also hit opponents while they are on the ground, a feature that was removed from the German version.

Enter the full health cheat (R2, R2, L1, R1, Left, Down, Right, Up, Left, Down, Right, Up) while in a vehicle and that vehicle's damage will be repaired. The visual damage will remain but the vehicle's condition will be as if it were new.

Get into a taxi, hold down the R3 button. Exit the taxi and step into another car, release the R3 button and you should be able to do taxi mission in the car you are currently in.

Get into a car. Drive in front of the desired car (to keep it front driving away) that you would like to drive after it's been blown up. THE CAR MUST HAVE SOMEONE IN IT. Walk up to the driver's side door. Enter the ''Blow up all cars'' code. While entering the code, Mr. GTA (or whatever his name is) will pull the driver out of the car and then get into it as it's blowing up and somehow he will not die. But as soon as you are in the car, enter the Health Code to extinguish the flame. It might not work the first time, so keep trying and eventually it will work.

If you want to get to the third Island and haven't earned it, you can ''fall'' into the underground passage. You'll need the Car Handling Cheat entered (R1 L1 R2 L1 left R1 R1 Triangle) and an esperanto. You must have an Esperanto - it's the only car that will jump high enough. First, get to the hospital in Staunton Island. then, go to the parking lot and go as fast as you can towards the Hospital. Make sure that you are on the left side of it... It's hard to do it without doing that. Jump onto the platform above the Hospital ''Entrance'' and go slowly straight to the square-looking wall. Go into it turning right, and go forward. You should fall out of the world and land in the underground passage. Turn right and go quicly to the beauty of Shoreside Vale. If you hit a blue wall, turn around and go.

When you're doing the mission on Staunton Island for Ray Machowski called ''Gone Fishing'', you're supposed to kill the guy on the boat. If you stand on the shore with your sniper rifle and shoot him as he goes by, he may turn the wrong direction and beach himself.

If you shoot him as he's standing on the shore, the boat remains. Press the Triangle button as you would to get into any other boat, and press the Square button like you're reversing. The boat won't go too far, but if you keep holding the Square button down, eventually you can get back into the water, assuming the boat doesn't flip.

The boat handles REALLY well, goes pretty fast, and goes by the title of ''GHOST Missing''. If you dock it and shoot it to make it explode, it does explode, but it still remains as though it's new. You can't really see yourself inside the boat, as it was never meant for you to drive anyways.

Little thing, but it's fun.

Go to any garage that can fit two or more cars in. When It is full, get another car right up next to the door, and get out. Press triangle as the door is going up, and hit X fast to get the car in. You might have to move the cars in the garage around, but it's possible to get up to 6 cars in any given garage.

To exploit this glitch it's just a matter of putting the fire out as the clock is going to hit 0. If done correctly, the timer will disappear allowing infinite time to cruise to the next fire.

At the first island drive your car towards the tunnel that blocks off the third and second island. Park the car right next to the blue wall and blow it up. You should be blown through into the third or second island.

Start a Vigilante mission. Once you get near the suspect's car. Hit pause, and then un-pause it. The suspect will jump out of the car for no reason. Now you can run them over.

You need a saved game for this. Start a new game, and after the beginning cutscene load your other game. You'll have everything, but you'll still be wearing a prisoner outfit.

Press the START button, go to the Audio menu, select the station you want to reset, then press the START button and press left or right to change the menu while the pause menu dissapears. For some reason, the radio station you selected will reset. You will notice the station track reset if you are in a car.

Take an ambulance to the top of Marco's Bistro in the St. Mark's area. It takes a bit of work, but you should be able to get it up the stairs eventually. Now, slowly back it up so that it almost rolls over the edge of the little wall, but not all the way. Now (quickly) find a car on the street and bring it in front of the ambulance so that you can jump on the ambulance's hood and then roof. While on the roof, jump towards the brick wall of the building. You should end up on an invisible ledge or roof and you can run around quite a large area before the invisible ground ends. Tip: Use a gun that you can aim manually to shoot the "ground" in front of you a bit. If there are sparks, then it's safe to walk, and if there aren't any than you will fall if you try to walk there.

Near the Traid Gang area, there is a subway entrance that is blocked off. It has stairs leading down to it. There is a ramp that causes you to fly over the small gap. But if you drive up very slowly then you will fall of the ramp and land on the stairs. If you done this correctly then you should go through the cage. You will now be in the subway. You will now be able to either take a train to another island or drive your car to another island through the subway. This glitch works well with a Police car or a Taxi.