Welcome to the Pinky, Elmyra & the Brain guide at TV.com. Pinky and the Brain, those two genetically engineered lab mice, are homeless now that Acme Labs is no more. And the mice are in need of a place to hide as a secret organization wants to apprehend Brain. While hiding in a pet shop, the mice wound up getting bought by Elmyra Duff. Now the mice are forced to operate from Elmyra's house and endure her twisted ways of caring for animals. Despite all of these new complications, Pinky and the Brain still continue to try to take over the world.

Each of the thirteen episodes were split into two ten minute parts, except for the tenth episode (or nineteenth part) which played for the full 22 minutes.

The series, however, was canceled after only five episodes (ten parts) had gone to air. The remaining eight episodes (fifteen parts) were moved to segments seen on the The Big Cartoonie Show, and with the exception of its first outing on the show (episode six, or parts eleven and twelve) and episode ten (part nineteen), each episode was split into its parts and shown a week apart. The episode ordering also changed from the original design.