Based in Berkeley with stores also in Walnut Creek and San Rafael, Elephant Pharm employed a total of about 190 people, including at its home office. A Los Altos location, which opened about two years ago, closed in the fall.

The company, which offered traditional prescriptions along with Chinese herbs, yoga supplies and other alternative products, cited the downturn in the economy for its decision to liquidate under Chapter 7 of the U.S. Bankruptcy Code.

"The company has been burdened with obligations that were quite difficult for a company of our size to carry," Elephant Pharm's chief executive officer, Kathi Lentzsch, said in a statement.

Over the past year, Elephant Pharm continued discussions with potential investors, cut costs and closed the Los Altos store in an unsuccessful effort to avoid Tuesday's decision, the company said.

"The current management team and board of directors worked diligently to grow the company to a size that could bear these obligations," Lentzsch said, "but due to the current economic conditions and the tightening of the credit market, it has not been possible to raise the capital required to continue the business."

Elephant Pharm, which opened its first store in Berkeley in 2002, was founded by self-described serial entrepreneur Stuart Skorman, who also started Reel.com and the now defunct Hungryminds.com at the height of the dot-com boom. In 2005, Lentzsch took over as CEO from Skorman, who is no longer involved in the company.

In the fall of 2005, the company raised $26 million from Tudor Investment and the Bay Area Equity Funds. Giant drugstore chain CVS also has invested in Elephant Pharm.

Customer Keith Gatto made a pilgrimage to Elephant Pharm's Berkeley store Tuesday from his office on the UC Berkeley campus because he couldn't believe it was closing.

"The feel I got from Elephant Pharmacy was that they were looking out for you and your health. It wasn't a transaction-based environment," said Gatto, 44, who appreciated the company's support of both Western and alternative therapies.

Jude Valentine, a Berkeley resident, said she wasn't surprised by the store's closure because she noticed recently that the store's shelves were emptier and some products were out of stock.

"What was great about that place was there were consultants that anyone could see - reputable people with credentials," said Valentine, 72. "A lot of times you could see one of their practitioners before you could get an appointment to see your doctor."

Valentine, who did not know where she would take her pharmacy business, said she attended the store's wellness classes and considered it a community center. "And you could get a prescription filled, by the way," she said.

The president of Elephant Pharm's chief competitor, Pharmaca Integrative Pharmacy, said he was sorry to see Elephant Pharm go out of business.

"You always want competition in your space because it keeps you on your toes and lends credibility to the model," said Mark Panzer of the Boulder, Colo., company. Pharmaca has 23 stores in five states including 13 in California.

But Panzer didn't think Elephant Pharm's troubles signaled similar problems for his company. "Our execution - complementary, alternative medicine coupled with traditional pharmacy - has been a model that resonates with our customers," he said, adding that the stores continue to show positive sales growth.

On Elephant Pharm's Web site, the company left this message to its customers: "It's been a very special six years since we started this drugstore revolution, and we certainly couldn't have made it as far as we did without you - our customers. We hope that you will continue your pursuit of a good, long life, well lived."

E-mail Victoria Colliver at vcolliver@sfchronicle.com.

This article appeared on page C - 1 of the San Francisco Chronicle