Throw your grenades under-handed by lightly holding the L1 button (or your aim button, if you changed your controls), instead of holding it down completely.

Equipping your cardboard box and staying still will keep your character safe from being locked on (but not from being shot manually).

If your character is set on fire, you can extinguish the flames by quickly equipping the cardboard box.

When playing as Snake in the online sneaking mode, you should avoid lit areas so your shadow will not be as apparent. Also, in stages where characters emit frosty breath, have Snake play dead while prone to make Snake's breath disappear.

The cardboard box may restrict your view, but it also keeps you safe from seeing magazines. If you think that someone has placed one behind the corner, equip the cardboard box to avoid it.

Trying to find a friend on Metal Gear Online but can't? That's because a player needs to log into their MGO account (and onto a server) before you to find them. Additionally, you "add" their MGO character name to your Friends List (for Metal Gear Online only), not any other Playstation Network game.

If you already know that equipping the box makes you immune to the porno magazine's effect, then you should try doing that while climbing a ladder. The game won't register the magazine since your character immediately goes into the box once he's off the ladder.

A lot of you probably know this but I'm just putting this out there since I camp the roofs in Urban Ultimatum and similar stages often. When your character is on a ladder, you can throw a grenades.