- O-Town
- O.A.R.
- The O.C. Supertones
- The Oak Ridge Boys
- Oak Ridge Boys
- The Oak Ridge Boys
- Oakenfold, Paul
- Oakland Interfaith Gospel Choir
- Oasis
- Oasis
- Obey, Ebenezer
- O'Brien, Tim
- Ocasek, Ric
- Ocean, Billy
- Ochs, Phil
- O'Connor, Mark
- O'Connor, Sinead
- O'Connor, Sinead
- O'Day, Anita
- Odds
- Odetta
- O'Farrill, Chico
- The Offspring
- O'Hara, Mary Margaret
- O'Hearn, Patrick
- The Ohio Players
- Oingo Boingo
- The O'Jays
- Ol' Dirty Bastard
- Olatunji, Babatunde
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